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Association details:
| Biomarker: | MAN1A1-ROS1 rearrangement |
|---|---|
| Cancer: | Leiomyosarcoma |
| Drug: | Xalkori (crizotinib) (ALK inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Identification of a Novel MAN1A1-ROS1 Fusion Gene Through mRNA-based Screening for Tyrosine Kinase Gene Aberrations in a Patient with Leiomyosarcoma
Excerpt:
We identified aberrant expression ratios regarding the 3’ to 5’ end of the kinase domain ratios in ROS1 transcripts in a leiomyosarcoma in a 90-year-old woman….Moreover, in an in vivo assay, crizotinib, a ROS1 inhibitor, markedly inhibited the growth of MAN1A1-ROS1 rearrangement-induced transformed cells in a dose-dependent manner.
DOI:
10.1097/CORR.0000000000001548
