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Association details:
| Biomarker: | MALAT1 overexpression |
|---|---|
| Cancer: | Non Small Cell Lung Cancer |
| Drug: | gemcitabine (DNA synthesis inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
MALAT1 enhances gemcitabine resistance in non-small cell lung cancer cells by directly affecting miR-27a-5p/PBOV1 axis
Published date:
04/04/2022
Excerpt:
MALAT1 was observed to be highly expressed in tissues and cells of GEM resistant patients. Forced level of MALAT1 could markedly enhance A549 cell resistance to GEM....MALAT1 facilitated tumor growth in vivo via targeting miR-27a-5p/PBOV1 and enhanced resistance of NSCLC cells to GEM.
DOI:
10.1016/j.cellsig.2022.110326
