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Association details:
| Biomarker: | LY75 expression |
|---|---|
| Cancer: | Solid Tumor |
| Drug: | OBT076 (Microtubule inhibitor, CD205-targeted antibody-drug conjugate) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
MEN1309/OBT076, a First-In-Class Antibody-Drug Conjugate Targeting CD205 in Solid Tumors
Excerpt:
MEN1309/OBT076 displayed selective and potent cytotoxic effects against tumor cells exhibiting strong and low to moderate CD205 expression. In vivo, MEN1309/OBT076 showed potent antitumor activity resulting in durable responses and complete tumor regressions in many TNBC, pancreatic, and bladder cancer cell line-derived and patient-derived xenograft models...Overall, our data demonstrate that MEN1309/OBT076 is a novel and selective ADC with potent activity against CD205-positive tumors. These data supported the clinical development of MEN1309/OBT076.
DOI:
10.1158/1535-7163.MCT-18-0624
