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Association details:
Biomarker:LPAR3 overexpression
Cancer:Ovarian Cancer
Drug:cisplatin (DNA synthesis inhibitor)
Direction:Resistant
Evidence:
Evidence Level:
Resistant: D – Preclinical
Title:

Circular RNA lysophosphatidic acid receptor 3 (circ-LPAR3) enhances the cisplatin resistance of ovarian cancer

Published date:
01/26/2022
Excerpt:
Our results showed that circ-LPAR3 was markedly upregulated in DDP-resistant OC tissues and cells.....To sum up, circ-LPAR3 might contribute to the DDP resistance of OC via the miR-634/PDK1 axis.
DOI:
10.1080/21655979.2022.2029109