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Association details:
| Biomarker: | Low EMT signature scores |
|---|---|
| Cancer: | Non Small Cell Lung Cancer |
| Drug: | Opdivo (nivolumab) (PD1 inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Gene signatures of tumor inflammation and epithelial-to-mesenchymal transition (EMT) predict responses to immune checkpoint blockade in lung cancer with high accuracy
Excerpt:
Both signatures demonstrated a satisfactory predictive accuracy for response: AUC of 0.69 (95% CI: 0.54, 0.84) for the inflammatory and 0.70 (95% CI: 0.55, 0.85) for EMT signatures, respectively....The EMT signature scores were significantly lower (more epithelial) in the responder cohort (average score= -1.7 ± 1.0) compared to nonresponders (average score = +2.1 ± 1.2)...
DOI:
10.1016/j.lungcan.2019.10.012
