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    Association details:
    Biomarker:LIFR D578N
    Cancer:Colorectal Cancer
    Drug:Erbitux (cetuximab) (EGFR inhibitor)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: D – Preclinical
    New
    Source:
    Br J Cancer
    Title:

    Feasibility of proposed single-nucleotide polymorphisms as predictive markers for targeted regimens in metastatic colorectal cancer

    Excerpt:
    For the cetuximab regimens, patients homozygous for the wild-type alleles (GG) of LIFR rs3729740 exhibited greater ORR and DCR…
    DOI:
    10.1038/bjc.2013.163