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Association details:
| Biomarker: | LGALS1 overexpression + LAG3 overexpression |
|---|---|
| Cancer: | Chronic Lymphocytic Leukemia |
| Drug: | OTX-008 (Galectin inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Single-Cell RNA Sequencing Suggests Novel Drivers of Chronic Lymphocytic Leukemia Patients with Ibrutinib Resistance
Published date:
11/04/2021
Excerpt:
A close correlation between LGALS1 and LAG3 expression was observed and both of them were found to be highly expressed in IBR CLL patients (Fig E)... patients with higher expression of both LGALS1 and LAG3 showed the poorest overall survival, indicating that LGALS1 and LAG3 are associated with ibrutinib-resistance and poor prognosis in CLL (Fig G)....LGALS1 inhibitor OTX008 effectively inhibits the growth of ibrutinib-resistant CLL cells, particularly for IBR patients...
DOI:
10.1182/blood-2021-149963
