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Association details:
| Biomarker: | LAMP1 expression |
|---|---|
| Cancer: | Colon Cancer |
| Drug: | SAR428926 (Microtubule inhibitor, LAMP1-targeted antibody-drug conjugate) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Abstract 1198: Characterization of a novel maytansinoid-antibody-drug conjugate targeting LAMP1 expressed at the surface of tumor cells
Excerpt:
PDX models reflecting the pattern and level of LAMP1 expression at the surface of human tumors were selected to evaluate SAR428926 in vivo efficacy. Outstanding in vivo activity was observed in different indications, including TNBC, lung and colon PDXs, with complete regressions after a single administration at 5 mg/kg.
DOI:
https://doi.org/10.1158/1538-7445.AM2016-1198
