Here, we found that LACTB overexpression significantly inhibited the cell proliferation in H1299 and H1975 cells treated with docetaxel, which indicates that LACTB has additive effects with docetaxel (Fig. 9A and ​andB).B)….These data suggest that LACTB might be applied to increase the efficacy of docetaxel in lung cancer therapy....As shown in Fig. 10A and ​andB,B, the cell apoptotic rate was 48.96% in the H1975 cells treated with the combination of LACTB and docetaxel while the rate was 33% in the Ctrl/docetaxel group, and the difference was significant....In conclusion, LACTB plays an additive role with docetaxel in the apoptosis of lung cancer cells.