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Association details:
| Biomarker: | KRAS wild-type |
|---|---|
| Cancer: | Rectal Cancer |
| Drug: | Erbitux (cetuximab) (EGFR inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Excerpt:
Rectal cancer: Systemic therapy for advanced or metastatic disease...FOLFOX + Cetuximab (KRAS/NRAS/BRAF WT only)...FOLFIRI + cetuximab (KRAS/NRAS/BRAF WT only)...FOLFIRINOX or mFOLFIRINOX + cetuximab...Irinotecan + cetuximab (KRAS/NRAS/BRAF WT only)
Secondary therapy:
FOLFOX; FOLFIRINOX; FOLFIRI; irinotecan
Source:
Title:
Cetuximab and/or Dasatinib in Patients With Colorectal Cancer and Liver Metastases That Can Be Removed by Surgery
Excerpt:
...- Although KRAS status will be evaluated in the tumor, wild type KRAS status is...
Trial ID:
Source:
Title:
Multicenter prospective single-arm study investigating the efficacy and safety of second-line cetuximab plus chemotherapy treatment in initially RAS-mt mCRC patients who converted to RAS-wt at the time of first progression Studio di fase II a singolo braccio di terapia di II linea con cetuximab e chemioterapia in pazienti con carcinoma colorettale metastatico KRAS e NRAS mutato alla diagnosi con assenza di mutazioni di KRAS/NRAS su plasma alla progressione da prima linea
Excerpt:
...• Consenso informato scritto nella fase di screening e nella fase di arruolamento• KRAS/NRAS wild-type su plasma (DNA tumorale circolante) al momento della progressione da prima linea di trattamento• Aspettativa di vita di almeno 3 mesi...
Trial ID:
More C2 evidence
Source:
Title:
Lenalidomide and Cetuximab in Treating Patients With Advanced Colorectal Cancer or Head and Neck Cancer
Excerpt:
...eligible malignancies include: colorectal cancer KRAS wild-type and squamous cell head and neck cancer...
Trial ID:
