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Association details:
| Biomarker: | KRAS Q22X |
|---|---|
| Cancer: | Colon Cancer |
| Drug: | Vectibix (panitumumab) (EGFR inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
A novel K-ras mutation in colorectal cancer. A case report and literature review.
Excerpt:
A 43-year-old female was diagnosed with an adenocarcinoma of the ascending colon...In order to use an anti-EGFR monoclonal antibody (panitumumab)-containing second-line regimen, it was decided to assess EGFR immunohistochemical expression and K-ras gene mutational status...A never-reported K-ras mutation (CAG>TAG) determining a premature stop signal at codon 22 (Gln22Stop) was found...The patient, however, was found to be unresponsive to an anti-EGFR MAb treatment.
