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Association details:
| Biomarker: | KRAS mutation |
|---|---|
| Cancer: | Non Small Cell Lung Cancer |
| Drug: | ganetespib (ADX-1612) (HSP90 inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Targeting KRAS-Mutant Non–Small Cell Lung Cancer with the Hsp90 Inhibitor Ganetespib
Excerpt:
The cytotoxic activity of ganetespib was initially evaluated in a panel of 20 NSCLC cell lines selected for expression of known KRAS mutations...Ganetespib potently reduced viability in all lines examined, with IC50 values in the low nanomolar range...
DOI:
10.1158/1535-7163.MCT-12-0615
