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Association details:
| Biomarker: | KRAS mutation |
|---|---|
| Cancer: | Lung Adenocarcinoma |
| Drug Class: | KRAS inhibitor |
| Direction: | Resistant |
Evidence:
Source:
Title:
Acquired Resistance to KRASG12C Inhibition in Cancer
Published date:
06/24/2021
Excerpt:
In two of nine patients with lung adenocarcinoma for whom paired tissue-biopsy samples were available, histologic transformation to squamous-cell carcinoma was observed without identification of any other resistance mechanisms. Using an in vitro deep mutational scanning screen, we systematically defined the landscape of KRAS mutations that confer resistance to KRASG12C inhibitors.
DOI:
10.1056/NEJMoa2105281
Trial ID:
