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Association details:
| Biomarker: | KRAS mutation |
|---|---|
| Cancer: | Juvenile Myelomonocytic Leukemia |
| Drug: | decitabine (DNMT inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Combination of DNA-hypomethylating agent and hematopoietic stem cell transplantation in treatment of juvenile myelomonocytic leukemia: A case report
Published date:
12/11/2020
Excerpt:
...we report our experience with a patient who suffered from recurrent fever, pallor, abdominal distention, leukocytosis, and thrombocytopenia with a silent past history and family history of somatic KRAS mutation….We arrived at a JMML diagnosis...negativity for the BCR-ABL fusion gene, positivity for somatic KRAS mutation...The patient presented with complete remission of the disease and mild graft versus host disease for 26 months after treatment with decitabine and HSCT.
DOI:
10.1097/MD.0000000000023606
