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Association details:
| Biomarker: | KRAS mutation + TP53 wild-type |
|---|---|
| Cancer: | Colon Cancer |
| Drug: | 5-fluorouracil (Thymidylate synthase inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
187 / 13 - High-throughput screening of cancer spheroids demonstrates sensitivity to combination chemotherapy
Published date:
03/09/2022
Excerpt:
Using the NaviPlate, we examined the response to chemotherapy of four commonly used cancer cell lines: LNCaP, AR mutant lymph-node derived prostate cancer; A549, KRAS mutant/EGFR wt NSCLC; HCT116, KRAS mutant/p53 wt colon cancer; and MDA-MB-231 triple negative breast cancer .First, the lines were exposed to three types of chemotherapy with distinct modes of action: 5-FU (DNA damage), Docetaxel (inhibition of microtubular polymerization) and Flavopiridiol (pan-CDK inhibition). Except for Flavopiridiol in A549 cells, all cell lines were resistant to chemotherapy...
