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Association details:
| Biomarker: | KRAS mutation + PD-L1 underexpression |
|---|---|
| Cancer: | Non Small Cell Lung Cancer |
| Drug: | Avastin (bevacizumab) (VEGF-A inhibitor) + Tecentriq (atezolizumab) (PD-L1 inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Clinical efficacy of atezolizumab plus bevacizumab and chemotherapy in KRAS-mutated non-small cell lung cancer with STK11, KEAP1, or TP53 comutations: subgroup results from the phase III IMpower150 trial
Published date:
02/21/2022
Excerpt:
In mKRAS patients, median PFS was longer in the ABCP arm than in the ACP or BCP arms in the PD-L1-high, PD-L1-low, and PD-L1-negative subgroups (figure 3C). PFS improvements in the ABCP vs BCP arm were similar among patients with PD-L1-high (HR 0.36; 95% CI 0.17 to 0.74), PD-L1-low (HR 0.22; 95% CI 0.08 to 0.60), and PD-L1-negative (HR 0.42; 95% CI 0.20 to 0.86) expression.
Secondary therapy:
Chemotherapy
DOI:
http://dx.doi.org/10.1136/jitc-2021-003027
Trial ID:
