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Association details:
| Biomarker: | KRAS G13 |
|---|---|
| Cancer: | Colorectal Cancer |
| Drug: | Erbitux (cetuximab) (EGFR inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Excerpt:
ERBITUX is not indicated for the treatment of patients with CRC that harbor somatic mutations in exon 2 (codons 12 and 13), exon 3 (codons 59 and 61), and exon 4 (codons 117 and 146) of either K-Ras or N-Ras and hereafter is referred to as “Ras” or when the Ras status is unknown.
Source:
Title:
Cetuximab Plus Irinotecan, Fluorouracil, and Leucovorin As First-Line Treatment for Metastatic Colorectal Cancer: Updated Analysis of Overall Survival According to Tumor KRAS and BRAF Mutation Status
Excerpt:
Mutations in KRAS codon 12 or 13 were detected in the tumor tissue of 397 of 1,063 patients (37%)...Patients in both treatment groups whose tumors carried mutations in KRAS appeared to have worse overall survival than those whose tumors were wild-type (Table 2, Fig 2B). Cox (PFS and overall survival) and logistic regression (best overall response) models were used to explore the relationship in the expanded KRAS population between the magnitude of treatment effect and tumor KRAS mutation status.
Secondary therapy:
FOLFIRI
DOI:
10.1200/JCO.2010.33.5091
Trial ID:
Source:
Title:
Randomised Phase II study of cetuximab alone or in combination with irinotecan in patients with metastatic colorectal cancer (CRC) with either KRAS WT or G13D mutation.
Excerpt:
...KRAS G13D ...
Trial ID:
Source:
Title:
A study to explore the effects of cetuximab alone or in combination with irinotecan in patients with an abnormal gene (KRAS) in their colon cancer cells.
Excerpt:
...Prior confirmation of tumour KRAS status as either KRAS WT (with no mutations or changes in BRAF, NRAS, PIK3CA exon20) OR KRAS G13D mutation,6. ...
Trial ID:
Less C2 evidence
Source:
Title:
Biomarkers of benefit from cetuximab-based therapy in metastatic colorectal cancer: interaction of EGFR ligand expression with RAS/RAF, PIK3CA genotypes
Excerpt:
Specifically, patients with codon 13 mutations reached a median survival of 28 months (95% CI 16–39), those with other rarer KRAS mutations a median survival of 33 months (95% CI 16–42) and patients with KRAS wild-type tumours a median survival of 29 months (95% CI 25–35).
DOI:
10.1186/1471-2407-13-49
Source:
Title:
A Molecularly Annotated Platform of Patient-Derived Xenografts (“Xenopatients”) Identifies HER2 as an Effective Therapeutic Target in Cetuximab-Resistant Colorectal Cancer
Excerpt:
When reconsidering response rates according to the mutational status of KRAS, we found that neither regression nor disease stabilization was achieved in any of the 18 cohorts bearing KRAS-mutant (codons 12 and 13) tumors.
DOI:
10.1158/2159-8290.CD-11-0109
