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Association details:
| Biomarker: | KRAS G12V |
|---|---|
| Cancer: | Solid Tumor |
| Drug: | QTX3034 (KRAS G12D inhibitor, KRAS inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
LB320 / 11 - Discovery and characterization of QTX3034, a potent, selective, and orally bioavailable allosteric KRAS inhibitor
Published date:
03/15/2023
Excerpt:
In a KRASG12V-driven xenograft model, oral administration of QTX3034 showed significant tumor growth inhibition, consistent with its activity against KRASG12V in vitro….Taken together, this preclinical characterization supports the advancement of QTX3034 into IND-enabling studies for KRAS mutant cancers.
