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Association details:
Evidence:
Evidence Level:
Sensitive: D – Preclinical
Source:
Title:

1104 - Repotrectinib increases effectiveness of MEK inhibitors in KRAS mutant cancer models

Published date:
03/10/2021
Excerpt:
Repotrectinib/trametinib and repotrectinib/VS-6766 combinations yielded significant effects on cancer cell viability in NSCLC and pancreatic patient-derived spheroid models harboring KRASG12D and KRASG12V mutations....the combination of repotrectinib with MEKi can repress the mutant KRAS signaling network to achieve more potent and durable anti-tumor activity and warrants clinical investigation in patients with KRASG12D and KRASG12V mutant cancers.