We report the case of a 58-year-old female Caucasian...who presented with cough and chest pain and was subsequently diagnosed with metastatic pulmonary adenocarcinoma....The tumor was positive for Kirsten rat sarcoma virus oncogene KRAS-G12C mutation and had high programmed death-1 ligand expression….She was then commenced on immunotherapy with nivolumab, with complete response for a total of 6 years. She does not report any adverse events. Currently, she shows no evidence of recurrence of non-small cell lung carcinoma.