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Association details:
| Biomarker: | KRAS G12A |
|---|---|
| Cancer: | Colorectal Cancer |
| Drug: | sunitinib (c-KIT inhibitor, VEGFR inhibitor, PDGFR inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
KRAS allel-specific activity of sunitinib in an isogenic disease model of colorectal cancer
Excerpt:
In the MTT chemosensitivity assay, the grade of resistance was less pronounced in G13D and highest in G12A, G12C, and G12S mutant cells.
DOI:
10.1007/s00432-013-1401-9
