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Association details:
| Biomarker: | KRAS G12A |
|---|---|
| Cancer: | Chronic Lymphocytic Leukemia |
| Drug: | GT19077 (MYC inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Abstract LB-111: GT19077, a c-Myc/Max protein-protein interaction (PPI) small molecule inhibitor, selectively targets c-Myc-additive B-cell and myeloid malignancies
Published date:
06/23/2020
Excerpt:
Profiling on the proliferation of a selected 14 hematologic malignant cell panel with c-Myc overexpression, GT19077 selectively inhibited the proliferation of all seven B-cell malignant cell lines tested, which include three carrying Myc-IGH translocations and two expressing Kras G12A mutations, with IC50s as low as 160 nM.
DOI:
10.1158/1538-7445.AM2020-LB-111
