^
Association details:
| Biomarker: | KLRG1 expression |
|---|---|
| Cancer: | Lymphoma |
| Drug: | Copiktra (duvelisib) (PI3Kδ inhibitor, PI3Kγ inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
937 KLRG1 Depletion Is a Novel Therapeutic Strategy for Patients with Mature T and NK/T-Cell Lymphomas
Published date:
11/03/2022
Excerpt:
We tested this combination in vivo using SMZ1 KLRG1+ subcutaneous xenografts in NSG mice. After 17 days of treatment, combination (mAb208 + Duv)- treated mice had a marked reduction in their mean tumor volumes (159 mm3) relative to mAb208 (1003 mm3 ; p=0.03), Duv (465.6 mm3 ; p=0.03) and CTL (2104 mm3 ; p=0.03) mice resulting in prolonged survival (Fig. 2).
DOI:
https://doi.org/10.1182/blood-2022-162583
