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Association details:
| Biomarker: | KLF4 overexpression |
|---|---|
| Cancer: | Colon Cancer |
| Drug: | cisplatin (DNA synthesis inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
KLF4 sensitizes the colon cancer cell HCT-15 to cisplatin by altering the expression of HMGB1 and hTERT
Excerpt:
We found that KLF4 expression sensitizes cancer cell to cisplatin cytotoxicity....This study suggests the involvement of KLF4-HMGB1/hTERT signaling in offering the basis for chemo-resistance in colon cancer cells and KLF4 overexpression as a probable strategy for sensitizing drug-resistant cancer cells to chemotherapy.
DOI:
10.1016/j.lfs.2019.02.005
