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Association details:
| Biomarker: | KLF4 A472D |
|---|---|
| Cancer: | Colorectal Cancer |
| Drug: | Erbitux (cetuximab) (EGFR inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
KLF4 p.A472D Mutation Contributes to Acquired Resistance to Cetuximab in Colorectal Cancer
Published date:
03/01/2020
Excerpt:
This study collected 17 plasma samples from patients with mCRC with cetuximab resistance...In particular, functional study of Krüppel-like factor 4 (KLF4) p.A472D revealed increased cetuximab resistance in colorectal cancer cells, which was associated with the increased phosphorylation of downstream EGFR signaling proteins.
DOI:
10.1158/1535-7163.MCT-18-1385
