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Association details:
| Biomarker: | KL overexpression |
|---|---|
| Cancer: | Lung Non-Small Cell Squamous Cancer |
| Drug: | pemetrexed (Thymidylate synthase inhibitor, THF dehydrogenase inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Antiaging gene Klotho regulates epithelial-mesenchymal transition and increases sensitivity to pemetrexed by inducing lipocalin-2 expression
Published date:
03/28/2021
Excerpt:
A549/KL-1 cells expressed higher levels of Klotho protein by western blot analysis compared with A549/KL-2 cells…The results of the sensitivity tests demonstrated that A549/KL-1 cells were significantly more sensitive to pemetrexed...Klotho expression during cancer treatment has great potential as a predictor for efficacy of pemetrexed...
DOI:
10.3892/ol.2021.12679