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Association details:
| Biomarker: | KIT positive |
|---|---|
| Cancer: | Acute Myelogenous Leukemia |
| Drug: | NN3201 (Microtubule inhibitor, c-KIT-targeted antibody-drug conjugate) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
In vivo efficacy and preclinical safety profile of NN3201, an anti-cKIT antibody-drug conjugate, for treating SCLC and AML
Published date:
04/04/2023
Excerpt:
NN3201 exhibited potent in vivo antitumor activities in cKIT-positive tumor cell line xenograft and patient-derived tumor xenograft models of SCLC and AML, representing robust and durable antitumor responses.
DOI:
https://doi.org/10.1158/1538-7445.AM2023-2648
