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Association details:
| Biomarker: | KIT positive |
|---|---|
| Cancer: | Acute Myelogenous Leukemia |
| Drug: | LOP628 (Microtubule inhibitor, c-KIT-targeted antibody-drug conjugate) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Preclinical Antitumor Activity of a Novel Anti-c-KIT Antibody-Drug Conjugate against Mutant and Wild-type c-KIT-Positive Solid Tumors
Excerpt:
The activity of the resulting ADC, LOP628, was evaluated in vitro against GIST, SCLC, and AML models and in vivo against GIST and SCLC models….LOP628 exhibited potent antiproliferative activity on c-KIT-positive cell lines, whereas LMJ729 displayed little to no effect.
DOI:
10.1158/1078-0432.CCR-17-3795
