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Association details:
| Biomarker: | KIT D820Y |
|---|---|
| Cancer: | Melanoma |
| Drug: | Sutent (sunitinib) (c-KIT inhibitor, VEGFR inhibitor, PDGFR inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Pathological activation of KIT in metastatic tumors of acral and mucosal melanomas
Excerpt:
Finally, we found significant growth suppressive effects of sunitinib in two acral melanoma cell lines; one harboring the D820Y mutation and one showing SCF-dependent KIT activation.
DOI:
10.1002/ijc.24048
