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Association details:
Biomarker:
KIM1 elevation
Cancer:
Renal Cell Carcinoma
Drug:
sorafenib
(
Multi-tyrosine kinase inhibitor
,
pan-RAF inhibitor
) +
sunitinib
(
c-KIT inhibitor
,
VEGFR inhibitor
,
PDGFR inhibitor
)
Direction:
Resistant
Evidence:
Evidence Level:
Resistant: C3 – Early Trials
Source:
ESMO 2019
Title:
PLASMA KIM-1 IS ASSOCIATED WITH CLINICAL OUTCOMES AFTER RESECTION FOR LOCALIZED RENAL CELL CARCINOMA: A TRIAL OF THE ECOG-ACRIN RESEARCH GROUP (E2805)
Published date:
09/30/2019
Excerpt:
Elevated plasma KIM-1 is associated with worse DFS and OS in patients with resected RCC, and therefore has potential as an adjuvant biomarker.
DOI:
10.1093/annonc/mdz239
Trial ID:
ASSURE
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