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Association details:
| Biomarker: | KIAA1217-RET fusion |
|---|---|
| Cancer: | Lung Adenocarcinoma |
| Drug: | Caprelsa (vandetanib) (Multi-tyrosine kinase inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Identification of a novel partner gene, KIAA1217, fused to RET: Functional characterization and inhibitor sensitivity of two isoforms in lung adenocarcinoma
Excerpt:
We observed that cells expressing KIAA1217-RET9 fusion protein were more sensitive to vandetanib than those expressing KIAA1217-RET51 and both isoforms attenuated cellular growth via cell cycle arrest.
DOI:
10.18632/oncotarget.9137
