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Association details:
| Biomarker: | KHDRBS1 overexpression |
|---|---|
| Cancer: | Renal Cell Carcinoma |
| Drug: | Sutent (sunitinib) (c-KIT inhibitor, VEGFR inhibitor, PDGFR inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Role of Sam68 in Sunitinib induced renal cell carcinoma apoptosis
Published date:
04/10/2022
Excerpt:
To determine the relationship between the levels of Sam68 expression and the sensitivity of RCC to sunitinib, an IHC assay was employed. Forty-seven paraffin-embedded tumor tissue samples of relapsed or metastatic RCC, including 16 sunitinib sensitive and 31 sunitinib resistant patients, were immunohistochemically stained. The IHC results revealed that the average Sam68 expression in sunitinib sensitive tumors was significantly higher than that in sunitinib resistant tumors...
DOI:
https://doi.org/10.1002/cam4.4743
