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Association details:
Biomarker:KEAP1 mutation + MSI-L/dMMR
Cancer:Lung Adenocarcinoma
Drug Class:Immunotherapy
Direction:Resistant
Evidence:
Evidence Level:
Resistant: C3 – Early Trials
Source:
Title:

Abstract 2226: Precise stratification of immunotherapy outcomes using response-associated somatic mutations

Published date:
06/22/2020
Excerpt:
All patients had received at least one dose of an ICI (anti-PD-1/PD-L1, anti-CTLA-4 or both)...we identified 14 ICI-response associated genes (IRAGs) across 6 cancer types. We verified that these IRAGs were predictive rather than prognostic...while 11 IRAGs were associated with worse outcomes in MSI-L tumors. When stratifying by both MSI and TMB status, we found that among TMB-L/MSI-L patients, 3 IRAGs in BLCA and 2 in LUAD were independently associated with worse outcomes.
DOI:
10.1158/1538-7445.AM2020-2226