^
Association details:
| Biomarker: | KEAP1 deletion |
|---|---|
| Cancer: | Lung Adenocarcinoma |
| Drug: | Tagrisso (osimertinib) (EGFR inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
Abstract 1094: Genetic determinants of EGFR-driven lung cancer growth and therapeutic response in vivo
Published date:
05/27/2020
Excerpt:
We also tested whether inactivation of any of the 10 TSGs was associated with a reduced response to TKIs, by treating mice infected with the lentiviral pool targeting the TSGs with the 3rd generation TKI osimertinib and found that loss of Keap1 was associated with a diminished response to therapy.
DOI:
10.1158/1538-7445.AM2020-1094
