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Association details:
Biomarker:
KDR V297L
Cancer:
Colorectal Cancer
Drug:
Avastin (bevacizumab)
(
VEGF-A inhibitor
)
Direction:
Sensitive
Evidence:
Evidence Level:
Sensitive: C3 – Early Trials
New
Source:
Clin Cancer Res
Title:
Pharmacogenetic angiogenesis profiling for first-line bevacizumab plus oxaliplatin-based chemotherapy in patients with metastatic colorectal cancer
Excerpt:
CXCR1 rs2234671 G>C, CXCR2 rs2230054 T>C, EGFR rs2227983 G>A and VEGFR-2 rs2305948 C>T were significantly associated with RR.
Secondary therapy:
oxaliplatin
DOI:
10.1158/1078-0432.CCR-11-1115
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