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Association details:
Biomarker:KDR expression
Cancer:Non Small Cell Lung Cancer
Drug Class:Immunotherapy
Direction:Resistant
Evidence:
Evidence Level:
Resistant: C3 – Early Trials
New
Source:
Title:

Vascular endothelial growth factor receptor 2 expression and immunotherapy efficacy in non-small cell lung cancer

Published date:
06/20/2022
Excerpt:
This retrospective, multicenter study included patients with advanced non–small cell lung cancer who were treated with immune-checkpoint inhibitors....Of 364 patients, 37 (10%) expressed vascular endothelial growth factor receptor 2 in immune cells and 165 (45%) in tumor cells....The objective response rate, progression-free survival and overall survival were significantly worse in patients treated with immune-checkpoint inhibitor monotherapy who expressed vascular endothelial growth factor receptor 2 in immune cells than those who did not (10% vs. 30%, p = 0.028; median = 2.2 vs. 3.6 months, p = 0.012; median = 7.9 vs. 17.0 months, p = 0.049, respectively).
DOI:
https://doi.org/10.1111/cas.15464