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Association details:
| Biomarker: | JAK1 mutation |
|---|---|
| Cancer: | Non Small Cell Lung Cancer |
| Drug Class: | Immunotherapy |
| Direction: | Resistant |
Evidence:
Source:
Title:
Microsatellite instability and mismatch repair deficiency define a distinct subset of lung cancers characterized by smoking exposure, high tumor mutational burden and recurrent somatic MLH1 inactivation.
Published date:
10/12/2023
Excerpt:
In NSCLC, STK11, KEAP1, and JAK1 were mutated in non-responders but wild type in responders.
DOI:
https://doi.org/10.1016/j.jtho.2023.10.004
