^
Association details:
| Biomarker: | IR overexpression + KRAS mutation |
|---|---|
| Cancer: | Colorectal Cancer |
| Drug: | BMS-754807 (IGF-1R inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
IRS2 Copy Number Gain, KRAS and BRAF Mutation Status as Predictive Biomarkers for Response to the IGF-1R/IR Inhibitor BMS-754807 in Colorectal Cancer Cell Lines
Excerpt:
...significant higher RNA levels of IR-A isoform were observed in KRAS/BRAF-WT only….in KRAS WT cell lines, BRAFV600E-mutated lines are not sensitive to the drug; and the ones having higher IR-A and/or lower IGFBP6 RNA expression levels, are more sensitive to BMS-754807.
DOI:
10.1158/1535-7163
