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Association details:
Biomarker:
IL32 overexpression
Cancer:
Melanoma
Drug:
Keytruda (pembrolizumab)
(
PD1 inhibitor
)
Direction:
Sensitive
Evidence:
Evidence Level:
Sensitive: C3 – Early Trials
New
Source:
JCI Insight
Title:
IL-32? potentiates tumor immunity in melanoma
Excerpt:
...increased baseline IL-32 gene expression was associated with response to nivolumab and pembrolizumab in two independent human melanoma patient cohorts, implying IL-32 as a predictive biomarker for anti-PD-1 therapy.
DOI:
10.1172/jci.insight.138772
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