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Association details:
| Biomarker: | IL13RA2 expression |
|---|---|
| Cancer: | Solid Tumor |
| Drug: | ADCT-211 (DNA replication inhibitor, IL-13Rα2-targeted antibody-drug conjugate) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Preclinical development of ADCT-211, a novel pyrrolobenzodiazepine dimer-based antibody-drug conjugate targeting solid tumors expressing IL13RA2
Published date:
03/15/2023
Excerpt:
In conclusion, ADCT-211 demonstrated potent and specific in vitro and in vivo anti-tumor activity and it was stable and well tolerated in the rat, warranting further development of ADCT-211 into the clinic in IL13RA2-expressing cancers.
