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Association details:
| Biomarker: | IL10 elevation |
|---|---|
| Cancer: | Peripheral T-cell Lymphoma |
| Regimen: | CHOP (cyclophosphamide + doxorubicin hydrochloride + + vincristine) |
| Direction: | Resistant |
Evidence:
Source:
Title:
Increased Serum Level of Interleukin-10 Predicts Poor Survival and Early Recurrence in Patients With Peripheral T-Cell Lymphomas
Published date:
10/13/2020
Excerpt:
...most patients received combination chemotherapy, including cyclophosphamide-doxorubicin-vincristine-prednisone (CHOP) or CHOP-like regimens...increased serum levels of IL-10 at diagnosis is related to the survival and early recurrence of PTCL patients. IL-10 ≥3.6 pg/ml is significantly correlated with lower CR rate, higher recurrence rate and lower OS rate. Furthermore, univariate and multivariate analysis indicated that IL-10 ≥3.6 pg/ml is an independent prognostic factor.
DOI:
10.3389/fonc.2020.584261
