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Association details:
| Biomarker: | IGF1R overexpression |
|---|---|
| Cancer: | Colorectal Cancer |
| Drug Class: | EGFR inhibitor |
| Direction: | Resistant |
Evidence:
Source:
Title:
Nuclear IGF-1R predicts chemotherapy and targeted therapy resistance in metastatic colorectal cancer
Published date:
11/09/2017
Excerpt:
...increased levels of nuclear p-IGF-1R expression in metastatic samples (after chemotherapy and after chemotherapy and anti-EGFR therapy)...the presence of high expression nuclear p-IGF-1R (⩾20%) showed a significantly inferior OS (median 16.7 months [95% CI, 13.4–20.2]) compared to low (1–19%) (median 24.6 months [95% CI 17.8–31.5]) and negative p-IGF-1R nuclear expression (median 30.5 months [95% CI 26.3–31.7]) (P<0.01).
Secondary therapy:
Chemotherapy
DOI:
10.1038/bjc.2017.279
