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Association details:
| Biomarker: | IGF1R overexpression + KRAS mutation |
|---|---|
| Cancer: | Colorectal Cancer |
| Drug: | BMS-754807 (IGF-1R inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
IRS2 Copy Number Gain, KRAS and BRAF Mutation Status as Predictive Biomarkers for Response to the IGF-1R/IR Inhibitor BMS-754807 in Colorectal Cancer Cell Lines
Excerpt:
Comparing with resistant lines, the sensitive cell lines had significantly higher levels of IGF-1R RNA expression only in KRAS-mutated subpopulation.
DOI:
10.1158/1535-7163
