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Association details:
| Biomarker: | IGF1 rs2016347 |
|---|---|
| Cancer: | Breast Cancer |
| Drug: | tamoxifen (Estrogen receptor antagonist) |
| Direction: | Resistant |
Evidence:
Source:
Title:
94P - Coexpression of PI3K/Akt signaling components and breast stem cells markers: Potential contributions in resistance to tamoxifen treatment
Published date:
09/14/2020
Excerpt:
Flow cytometry was used to evaluate the expression levels of CD326+CD44+CD24-/low, p-Akt473, PTEN, IGFR1 (CD221) and their combinations in fresh frozen breast cancer samples from 59 patients who developed distant metastasis....We observed higher frequency of G allele of IGFR1 rs2016347 among patients who did not benefit from tamoxifen treatment compare to tamoxifen sensitive patients (P=0.046).
