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Association details:
| Biomarker: | IFNG gene signature overexpression |
|---|---|
| Cancer: | Melanoma |
| Drug Class: | Immunotherapy |
| Direction: | Sensitive |
Evidence:
Source:
Title:
898 Demonstration of the utility of real-world progression-free survival (rwPFS) by application of an IFN-γ-related signature in a real-world cohort of patients with melanoma
Published date:
11/04/2023
Excerpt:
112 patients in the melanoma cohort had immune-checkpoint inhibitor (ICI) therapy...Groups derived from a median cut of the IFN-γ-related signature demonstrated a marginally significant association with rwPFS (p=0.059). Higher expression of the signature associated with longer survival (figure 1)...The observation of longer rwPFS in the high IFN-γ-related signature group corresponds with the original report of the signature, in which high expression of the signature was associated with a favorable response to ICI treatment.
DOI:
10.1136/jitc-2023-SITC2023.0898
Trial ID:
