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Association details:
| Biomarker: | IDH1 mutation + Chr del(1p) + Chr del(19q) |
|---|---|
| Cancer: | Glioma |
| Drug: | decitabine (DNMT inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
TERT and DNMT1 expression predict sensitivity to decitabine in gliomas
Excerpt:
IDH1-mutant glioma tumorspheres with hemizygous co-deletion of chromosome arms 1p/19q were particularly sensitive to DAC and showed significant inhibition of DNA replication genes.
