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Association details:
| Biomarker: | IDH1 mutation + BRAF V600E |
|---|---|
| Cancer: | Astrocytoma |
| Drug: | Zelboraf (vemurafenib) (BRAF inhibitor, BRAF V600E inhibitor) + Cotellic (cobimetinib) (MEK1 inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Excerpt:
ADULT GLIOMA: IDH-MUTANT ASTROCYTOMA….Recurrent or Progressive Disease WHO grade 2, KPS ≥60...Useful in Certain Circumstances...BRAF V600E activation mutation...BRAF/MEK inhibitors:…Vemurafenib/cobimetinib
