^
Association details:
| Biomarker: | IDH wild-type |
|---|---|
| Cancer: | Glioma |
| Drug: | Fibromun (onfekafusp alfa) (TNFα inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Turning the immunologically cold microenvironment of glioma into a hot one: a phase I/II study to evaluate safety and preliminary activity of the antibody-cytokine fusion protein L19TNF in patients with glioblastoma at first relapse
Published date:
03/15/2022
Excerpt:
Here we will present results of a phase I/II open label, non-randomized study that investigated the safety and single agent activity of L19TNF for patients with isocitrate dehydrogenase (IDH) wildtype World Health Organization (WHO) grade 3 or 4 glioma at first relapse....These studies showed a treatment-associated emerging tumor necrosis and changes in the complex immune infiltrate in the tumor tissue upon L19TNF, suggesting a local anti-tumor immune response.
DOI:
https://doi.org/10.14791/btrt.2022.10.F-1394
Trial ID:
