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Association details:
| Biomarker: | ICAM1 overexpression |
|---|---|
| Cancer: | Multiple Myeloma |
| Drug: | AIC100 (ICAM-1-targeted CAR-T immunotherapy) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
121 ICAM-1-specific affinity tuned CAR T cells expressing SSTR2 for real-time imaging
Published date:
11/09/2021
Excerpt:
A single dose of AIC100 resulted in tumor elimination and significantly improved survival of animals. AIC100 activity was confirmed in other high ICAM-1 tumor models including breast, gastric, and multiple myeloma.
DOI:
http://dx.doi.org/10.1136/jitc-2021-SITC2021.121
