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Association details:
| Biomarker: | HUWE1 mutation |
|---|---|
| Cancer: | Cervical Cancer |
| Drug: | GS-626510 (BET inhibitor, BRD4 inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Abstract 5341: Derangements in HUWE1/c-MYC pathway confer sensitivity to the BET bromodomain inhibitor GS-626510 in uterine cervical carcinoma
Published date:
05/15/2020
Excerpt:
HUWE1 and c-MYC expression were evaluated by qRT-PCR in a total of 23 CC including 12 fresh frozen tumor tissues and 11 primary cell lines….GS-626510 may represent a novel, potentially highly effective therapeutic agent against CC overexpressing c-MYC and/or harboring HUWE1 mutations.
DOI:
10.1158/1538-7445.AM2020-5341
